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Target
Trace amine-associated receptor 1
Ligand
BDBM50359505
Substrate
n/a
Meas. Tech.
ChEMBL_1643986 (CHEMBL3992915)
EC50
1690±n/a nM
Citation
 Tonelli, M; Espinoza, S; Gainetdinov, RR; Cichero, E Novel biguanide-based derivatives scouted as TAAR1 agonists: Synthesis, biological evaluation, ADME prediction and molecular docking studies. Eur J Med Chem 127:781-792 (2017) [PubMed]  Article 
Target
Name:
Trace amine-associated receptor 1
Synonyms:
TA1 | TAAR1 | TAAR1_HUMAN | TAR1 | TRAR1 | trace amine-associated receptor 1
Type:
PROTEIN
Mol. Mass.:
39107.47
Organism:
Homo sapiens (Human)
Description:
ChEMBL_792734
Residue:
339
Sequence:
MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS
  
Inhibitor
Name:
BDBM50359505
Synonyms:
CHEMBL1182312
Type:
Small organic molecule
Emp. Form.:
C14H14INO2
Mol. Mass.:
355.1709
SMILES:
NCCc1ccc(Oc2ccc(O)cc2)c(I)c1
Structure:
Search PDB for entries with ligand similarity: