Reaction Details Report a problem with these data
Target
Trace amine-associated receptor 1
Ligand
BDBM50053595
Substrate
n/a
Meas. Tech.
ChEMBL_1643990 (CHEMBL3992919)
EC50
>10000±n/a nM
Citation
 Tonelli, M; Espinoza, S; Gainetdinov, RR; Cichero, E Novel biguanide-based derivatives scouted as TAAR1 agonists: Synthesis, biological evaluation, ADME prediction and molecular docking studies. Eur J Med Chem 127:781-792 (2017) [PubMed]  Article 
Target
Name:
Trace amine-associated receptor 1
Synonyms:
TA1 | TAAR1 | TAAR1_HUMAN | TAR1 | TRAR1 | trace amine-associated receptor 1
Type:
PROTEIN
Mol. Mass.:
39107.47
Organism:
Homo sapiens (Human)
Description:
ChEMBL_792734
Residue:
339
Sequence:
MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS
  
Inhibitor
Name:
BDBM50053595
Synonyms:
4-Chloro-Phenyl biguanide | 4-Chlorophenylbiguanide | CHEMBL840 | N-(4-chlorophenyl)imidodicarbonimidic diamide
Type:
Small organic molecule
Emp. Form.:
C8H10ClN5
Mol. Mass.:
211.652
SMILES:
NC(=N)N=C(N)Nc1ccc(Cl)cc1 |w:3.2|
Structure:
Search PDB for entries with ligand similarity: