Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM50230302
Substrate
n/a
Meas. Tech.
ChEMBL_1644750 (CHEMBL3993679)
EC50
2060±n/a nM
Citation
 Krasavin, M; Lukin, A; Bagnyukova, D; Zhurilo, N; Golovanov, A; Zozulya, S; Zahanich, I; Moore, D; Tikhonova, IG Polar aromatic periphery increases agonist potency of spirocyclic free fatty acid receptor (GPR40) agonists inspired by LY2881835. Eur J Med Chem 127:357-368 (2017) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM50230302
Synonyms:
CHEMBL4077784
Type:
Small organic molecule
Emp. Form.:
C34H41ClFNO5
Mol. Mass.:
598.144
SMILES:
Cl.OC(=O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)CC(CCOc3ccc(F)cc3)CCO4)cc2)cc1
Structure:
Search PDB for entries with ligand similarity: