Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM50230310
Substrate
n/a
Meas. Tech.
ChEMBL_1644750 (CHEMBL3993679)
EC50
1140±n/a nM
Citation
 Krasavin, M; Lukin, A; Bagnyukova, D; Zhurilo, N; Golovanov, A; Zozulya, S; Zahanich, I; Moore, D; Tikhonova, IG Polar aromatic periphery increases agonist potency of spirocyclic free fatty acid receptor (GPR40) agonists inspired by LY2881835. Eur J Med Chem 127:357-368 (2017) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM50230310
Synonyms:
CHEMBL4091587
Type:
Small organic molecule
Emp. Form.:
C34H45Cl2N3O5
Mol. Mass.:
646.644
SMILES:
Cl.Cl.Cc1cnc(C)c(OCCC2CCOC3(CCN(Cc4ccc(COc5ccc(CCC(O)=O)cc5)cc4)CC3)C2)n1
Structure:
Search PDB for entries with ligand similarity: