Reaction Details Report a problem with these data
Target
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Ligand
BDBM50231791
Substrate
n/a
Meas. Tech.
ChEMBL_1645572 (CHEMBL3994501)
EC50
4060±n/a nM
Citation
 Li, L; Jiang, X; Huang, S; Ying, Z; Zhang, Z; Pan, C; Li, S; Wang, X; Zhang, Z Discovery of Highly Potent 2-Sulfonyl-Pyrimidinyl Derivatives for Apoptosis Inhibition and Ischemia Treatment. ACS Med Chem Lett 8:407-412 (2017) [PubMed]  Article 
Target
Name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Synonyms:
1.3.5.1 | Iron-sulfur subunit of complex II | SDH | SDH1 | SDHB | SDHB_HUMAN | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Type:
PROTEIN
Mol. Mass.:
31643.02
Organism:
Homo sapiens (Human)
Description:
ChEMBL_117429
Residue:
280
Sequence:
MAAVVALSLRRRLPATTLGGACLQASRGAQTAAATAPRIKKFAIYRWDPDKAGDKPHMQTYEVDLNKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTNLNKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSLYRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKEKKASV
  
Inhibitor
Name:
BDBM50231791
Synonyms:
CHEMBL4074296 | US11725000, Compound 118
Type:
Small organic molecule
Emp. Form.:
C19H13F3N4O3S
Mol. Mass.:
434.392
SMILES:
CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(=O)n(Cc2cccc(c2)C#N)c1
Structure:
Search PDB for entries with ligand similarity: