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Target
Lysyl oxidase homolog 2
Ligand
BDBM50232679
Substrate
n/a
Meas. Tech.
ChEMBL_1648494 (CHEMBL3997550)
IC50
136±n/a nM
Citation
 Hutchinson, JH; Rowbottom, MW; Lonergan, D; Darlington, J; Prodanovich, P; King, CD; Evans, JF; Bain, G Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX. ACS Med Chem Lett 8:423-427 (2017) [PubMed]  Article 
Target
Name:
Lysyl oxidase homolog 2
Synonyms:
1.4.3.13 | LOXL2_RAT | Loxl2 | Lysyl oxidase homolog 2 | Lysyl oxidase-like protein 2
Type:
PROTEIN
Mol. Mass.:
87182.46
Organism:
Rattus norvegicus
Description:
ChEMBL_117513
Residue:
776
Sequence:
MEIPFGSCLYSCLALLVLLPSLSLAQYESWPYQLQYPEYFQQPPPEHHQHQVPSDVVKIQVRLAGQKRKHNEGRVEVYYEGQWGTVCDDDFSIHAAHVVCREVGYVEAKSWTASSSYGPGEGPIWLDNIYCTGKESTLAACSSNGWGVTDCKHPEDVGVVCSEKRIPGFKFDNSLINQIESLNIQVEDIRIRPILSAFRHRKPVTEGYVEVKEGKAWKQICDKHWTAKNSHVVCGMFGFPAEKTYNPKAYKTFASRRKLRYWKFSMNCTGTEAHISSCKLGPPMFRDPVKNATCENGQPAVVSCVPSQIFSPDGPSRFRKAYKPEQPLVRLRGGAQVGEGRVEVLKNGEWGTVCDDKWDLVSASVVCRELGFGTAKEAVTGSRLGQGIGPIHLNEVQCTGTEKSIIDCKLNTESQGCNHEEDAGVRCNIPIMGFQKKVRLNGGRNPYEGRVEVLTERNGSLVWGNVCGQNWGIVEAMVVCRQLGLGFASNAFQETWYWHGNIFANKVIMSGVKCSGTELSLAHCRHDEEVVCPEGGVQYGAGVACSETAPDLVLNAEIVQQTAYLEDRPMALLQCAMEENCLSASAVHTDPTRGHRRLLRFSSQIHNNGQSDFRPKNGRHAWIWHDCHRHYHSMEVFTYYDLLSLNGTKVAEGHKASFCLEDTECEGDIQKSYECANFGEQGITMGCWDMYRHDIDCQWIDITDVPPGDYLFQVVINPNYEVPESDFSNNIMKCRSRYDGYRIWMYNCHVGGAFSEETEQKFEHFSGLLNNQLSVQ
  
Inhibitor
Name:
BDBM50232679
Synonyms:
CHEMBL4068784 | US11358936, Compound 4-5
Type:
Small organic molecule
Emp. Form.:
C6H7ClN2
Mol. Mass.:
142.586
SMILES:
NCc1ccnc(Cl)c1
Structure:
Search PDB for entries with ligand similarity: