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Target
Serine/threonine-protein kinase Nek2
Ligand
BDBM50235007
Substrate
n/a
Meas. Tech.
ChEMBL_1654329 (CHEMBL4003695)
IC50
87±n/a nM
Citation
 Xi, JB; Fang, YF; Frett, B; Zhu, ML; Zhu, T; Kong, YN; Guan, FJ; Zhao, Y; Zhang, XW; Li, HY; Ma, ML; Hu, W Structure-based design and synthesis of imidazo[1,2-a]pyridine derivatives as novel and potent Nek2 inhibitors with in vitro and in vivo antitumor activities. Eur J Med Chem 126:1083-1106 (2017) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Nek2
Synonyms:
NEK kinase | NEK2 | NEK2A | NEK2_HUMAN | NLK1
Type:
Enzyme
Mol. Mass.:
51776.96
Organism:
Homo sapiens (Human)
Description:
P51955
Residue:
445
Sequence:
MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR
  
Inhibitor
Name:
BDBM50235007
Synonyms:
CHEMBL4087758
Type:
Small organic molecule
Emp. Form.:
C28H27FN6O2
Mol. Mass.:
498.5514
SMILES:
CN(C)CCn1cc(cn1)-c1ccn2c(cnc2c1)-c1ccc(C(N)=O)c(OCc2ccccc2F)c1
Structure:
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