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Target
Potassium voltage-gated channel subfamily D member 3
Ligand
BDBM50235250
Substrate
n/a
Meas. Tech.
ChEMBL_1655140 (CHEMBL4004506)
IC50
8300±n/a nM
Citation
 Wolkenberg, SE; Nolt, MB; Bilodeau, MT; Trotter, BW; Manley, PJ; Kett, NR; Nanda, KK; Wu, Z; Cato, MJ; Kane, SA; Kiss, L; Spencer, RH; Wang, J; Lynch, JJ; Regan, CP; Stump, GL; Li, B; White, R; Yeh, S; Dinsmore, CJ; Lindsley, CW; Hartman, GD Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics. Bioorg Med Chem Lett 27:1062-1069 (2017) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily D member 3
Synonyms:
KCND3 | KCND3_HUMAN | Kv channel-interacting protein 2/Potassium voltage-gated channel subfamily D member 3 | Potassium voltage-gated channel subfamily D member 3 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv4.3
Type:
PROTEIN
Mol. Mass.:
73464.62
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1478652
Residue:
655
Sequence:
MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERLMDDNDSENNQESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCGTVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELTGTPEEEHMGKTTSLIESQHHHLLHCLEKTTGLSYLVDDPLLSVRTSTIKNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHPGLTTTCCSRRSKKTTHLPNSNLPATRLRSMQELSTIHIQGSEQPSLTTSRSSLNLKADDGLRPNCKTSQITTAIISIPTPPALTPEGESRPPPASPGPNTNIPSIASNVVKVSAL
  
Inhibitor
Name:
BDBM50235250
Synonyms:
CHEMBL4104525
Type:
Small organic molecule
Emp. Form.:
C23H17Cl2N3O
Mol. Mass.:
422.307
SMILES:
O[C@H](C(c1cccnc1)c1cccnc1)c1cccnc1-c1cc(Cl)cc(Cl)c1 |r|
Structure:
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