Reaction Details Report a problem with these data
Target
Hepatocyte growth factor-like protein
Ligand
BDBM50235820
Substrate
n/a
Meas. Tech.
ChEMBL_1658116 (CHEMBL4007728)
IC50
>10000±n/a nM
Citation
 Hoemann, M; Wilson, N; Argiriadi, M; Banach, D; Burchat, A; Calderwood, D; Clapham, B; Cox, P; Duignan, DB; Konopacki, D; Somal, G; Vasudevan, A Synthesis and optimization of furano[3,2-d]pyrimidines as selective spleen tyrosine kinase (Syk) inhibitors. Bioorg Med Chem Lett 26:5562-5567 (2016) [PubMed]  Article 
Target
Name:
Hepatocyte growth factor-like protein
Synonyms:
D3F15S2 | DNF15S2 | HGFL | HGFL_HUMAN | Hepatocyte growth factor-like protein | Hepatocyte growth factor-like protein alpha chain | Hepatocyte growth factor-like protein beta chain | MSP | MST1 | Macrophage stimulatory protein | Macrophage-stimulating protein
Type:
PROTEIN
Mol. Mass.:
80336.23
Organism:
Homo sapiens (Human)
Description:
ChEMBL_101427
Residue:
711
Sequence:
MGWLPLLLLLTQCLGVPGQRSPLNDFQVLRGTELQHLLHAVVPGPWQEDVADAEECAGRCGPLMDCRAFHYNVSSHGCQLLPWTQHSPHTRLRRSGRCDLFQKKDYVRTCIMNNGVGYRGTMATTVGGLPCQAWSHKFPNDHKYTPTLRNGLEENFCRNPDGDPGGPWCYTTDPAVRFQSCGIKSCREAACVWCNGEEYRGAVDRTESGRECQRWDLQHPHQHPFEPGKFLDQGLDDNYCRNPDGSERPWCYTTDPQIEREFCDLPRCGSEAQPRQEATTVSCFRGKGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTPEKYACKDLRENFCRNPDGSEAPWCFTLRPGMRAAFCYQIRRCTDDVRPQDCYHGAGEQYRGTVSKTRKGVQCQRWSAETPHKPQFTFTSEPHAQLEENFCRNPDGDSHGPWCYTMDPRTPFDYCALRRCADDQPPSILDPPDQVQFEKCGKRVDRLDQRRSKLRVVGGHPGNSPWTVSLRNRQGQHFCGGSLVKEQWILTARQCFSSCHMPLTGYEVWLGTLFQNPQHGEPSLQRVPVAKMVCGPSGSQLVLLKLERSVTLNQRVALICLPPEWYVVPPGTKCEIAGWGETKGTGNDTVLNVALLNVISNQECNIKHRGRVRESEMCTEGLLAPVGACEGDYGGPLACFTHNCWVLEGIIIPNRVCARSRWPAVFTRVSVFVDWIHKVMRLG
  
Inhibitor
Name:
BDBM50235820
Synonyms:
CHEMBL4066664
Type:
Small organic molecule
Emp. Form.:
C15H11F3N6O
Mol. Mass.:
348.2826
SMILES:
FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
Structure:
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