Reaction Details Report a problem with these data
Target
Cytochrome P450 2C9
Ligand
BDBM257207
Substrate
n/a
Meas. Tech.
ChEMBL_1660519 (CHEMBL4010131)
IC50
>50000±n/a nM
Citation
Scott, JD; DeMong, DE; Greshock, TJ; Basu, K; Dai, X; Harris, J; Hruza, A; Li, SW; Lin, SI; Liu, H; Macala, MK; Hu, Z; Mei, H; Zhang, H; Walsh, P; Poirier, M; Shi, ZC; Xiao, L; Agnihotri, G; Baptista, MA; Columbus, J; Fell, MJ; Hyde, LA; Kuvelkar, R; Lin, Y; Mirescu, C; Morrow, JA; Yin, Z; Zhang, X; Zhou, X; Chang, RK; Embrey, MW; Sanders, JM; Tiscia, HE; Drolet, RE; Kern, JT; Sur, SM; Renger, JJ; Bilodeau, MT; Kennedy, ME; Parker, EM; Stamford, AW; Nargund, R; McCauley, JA; Miller, MW Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity. J Med Chem 60:2983-2992 (2017) [PubMed] Article
More Info.:
Target
Name:
Cytochrome P450 2C9
Synonyms:
(R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | CP2C9_HUMAN | CYP2C10 | CYP2C9 | CYPIIC9 | Cytochrome P450 2C9 (CYP2C9 ) | Cytochrome P450 2C9 (CYP2C9) | P-450MP | P450 MP-4/MP-8 | P450 PB-1 | S-mephenytoin 4-hydroxylase
Type:
Enzyme
Mol. Mass.:
55636.33
Organism:
Homo sapiens (Human)
Description:
P11712
Residue:
490
Sequence:
MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPV