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Target
Cytochrome P450 2D6
Ligand
BDBM257207
Substrate
n/a
Meas. Tech.
ChEMBL_1660518 (CHEMBL4010130)
IC50
>50000±n/a nM
Citation
 Scott, JD; DeMong, DE; Greshock, TJ; Basu, K; Dai, X; Harris, J; Hruza, A; Li, SW; Lin, SI; Liu, H; Macala, MK; Hu, Z; Mei, H; Zhang, H; Walsh, P; Poirier, M; Shi, ZC; Xiao, L; Agnihotri, G; Baptista, MA; Columbus, J; Fell, MJ; Hyde, LA; Kuvelkar, R; Lin, Y; Mirescu, C; Morrow, JA; Yin, Z; Zhang, X; Zhou, X; Chang, RK; Embrey, MW; Sanders, JM; Tiscia, HE; Drolet, RE; Kern, JT; Sur, SM; Renger, JJ; Bilodeau, MT; Kennedy, ME; Parker, EM; Stamford, AW; Nargund, R; McCauley, JA; Miller, MW Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity. J Med Chem 60:2983-2992 (2017) [PubMed]  Article 
Target
Name:
Cytochrome P450 2D6
Synonyms:
CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:
Protein
Mol. Mass.:
55774.82
Organism:
Homo sapiens (Human)
Description:
P10635
Residue:
497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR
  
Inhibitor
Name:
BDBM257207
Synonyms:
US9493440, 51
Type:
Small organic molecule
Emp. Form.:
C21H25N5O2
Mol. Mass.:
379.4555
SMILES:
C[C@H]1CN(C[C@@H](C)O1)c1cc(ncn1)-c1n[nH]c2ccc(OC3(C)CC3)cc12 |r|
Structure:
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