Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50238514
Substrate
n/a
Meas. Tech.
ChEMBL_1663652 (CHEMBL4013333)
EC50
>10000±n/a nM
Citation
 Carpenter, J; Carpenter, J; Wang, Y; Wang, Y; Wu, G; Wu, G; Feng, J; Feng, J; Ye, XY; Ye, XY; Morales, CL; Morales, CL; Broekema, M; Broekema, M; Rossi, KA; Rossi, KA; Miller, KJ; Miller, KJ; Murphy, BJ; Murphy, BJ; Wu, G; Wu, G; Malmstrom, SE; Malmstrom, SE; Azzara, AV; Azzara, AV; Sher, PM; Sher, PM; Fevig, JM; Fevig, JM; Alt, A; Alt, A; Bertekap, RL; Bertekap, RL; Cullen, MJ; Cullen, MJ; Harper, TM; Harper, TM; Foster, K; Foster, K; Luk, E; Luk, E; Xiang, Q; Xiang, Q; Grubb, MF; Grubb, MF; Robl, JA; Robl, JA; Wacker, DA; Wacker, DA Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5-HT J Med Chem 60:6166-6190 (2017) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM50238514
Synonyms:
CHEMBL4095818
Type:
Small organic molecule
Emp. Form.:
C20H20N2O2S
Mol. Mass.:
352.45
SMILES:
Cc1nc(sc1C(=O)N1CCC(O)CC1)-c1cccc2ccccc12
Structure:
Search PDB for entries with ligand similarity: