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Target
Acid ceramidase
Ligand
BDBM50238566
Substrate
n/a
Meas. Tech.
ChEMBL_1663376 (CHEMBL4013057)
IC50
505±n/a nM
Citation
 Ortega, JA; Arencibia, JM; La Sala, G; Borgogno, M; Bauer, I; Bono, L; Braccia, C; Armirotti, A; Girotto, S; Ganesan, A; De Vivo, M Pharmacophore Identification and Scaffold Exploration to Discover Novel, Potent, and Chemically Stable Inhibitors of Acid Ceramidase in Melanoma Cells. J Med Chem 60:5800-5815 (2017) [PubMed]  Article 
Target
Name:
Acid ceramidase
Synonyms:
ASAH | ASAH1 | ASAH1_HUMAN | Acid ceramidase | Acid ceramidase (AC)
Type:
Enzyme
Mol. Mass.:
44662.65
Organism:
Homo sapiens (Human)
Description:
Q13510
Residue:
395
Sequence:
MPGRSCVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYKRWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVVDEKLPGLLGNFPGPFEEEMKGIAAVTDIPLGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTKPVLNKLTVYTTLIDVTKGQFETYLRDCPDPCIGW
  
Inhibitor
Name:
BDBM50238566
Synonyms:
CHEMBL4075846
Type:
Small organic molecule
Emp. Form.:
C16H15N3O
Mol. Mass.:
265.3098
SMILES:
Cc1ccc(CNC(=O)n2cnc3ccccc23)cc1
Structure:
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