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Target
Casein kinase I isoform delta
Ligand
BDBM274858
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
0.200±n/a nM
Comments
extracted
Citation
 Velaparthi, U; Darne, CP; Dodd, DS; Sampognaro, AJ; Wittman, MD; Kumaravel, S; Mullick, D; Liu, P; Rachamreddy, CR Substituted imidazoles as casein kinase 1 D/E inhibitors US Patent  US9556179 Publication Date 1/31/2017 
Target
Name:
Casein kinase I isoform delta
Synonyms:
CKI-delta | CKId | CSNK1D | Casein kinase 1 delta (CK1δ) | Casein kinase I delta | Casein kinase I isoform alpha/delta | Casein kinase I isoform delta (CK1D) | HCKID | KC1D_HUMAN | casein kinases 1 delta (CK1 delta)
Type:
Enzyme
Mol. Mass.:
47356.76
Organism:
Homo sapiens (Human)
Description:
P48730
Residue:
415
Sequence:
MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNISSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
  
Inhibitor
Name:
BDBM274858
Synonyms:
N-(6-(4-(4-Fluorophenyl)- 1-(tetrahydro-2H- pyran-4-yl)-1H-imidazol- 5-yl)imidazo[1,2- b]pyridazin-2-yl)-3- (pyridin-3-yl)benzamide | US9556179, Compound 435
Type:
Small organic molecule
Emp. Form.:
C32H26FN7O2
Mol. Mass.:
559.5929
SMILES:
Fc1ccc(cc1)-c1ncn(C2CCOCC2)c1-c1ccc2nc(NC(=O)c3cccc(c3)-c3cccnc3)cn2n1
Structure:
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