Reaction Details Report a problem with these data
Target
Casein kinase I isoform delta
Ligand
BDBM274891
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
2.30±n/a nM
Comments
extracted
Citation
Velaparthi, U; Darne, CP; Dodd, DS; Sampognaro, AJ; Wittman, MD; Kumaravel, S; Mullick, D; Liu, P; Rachamreddy, CR Substituted imidazoles as casein kinase 1 D/E inhibitors US Patent US9556179 Publication Date 1/31/2017
More Info.:
Target
Name:
Casein kinase I isoform delta
Synonyms:
CKI-delta | CKId | CSNK1D | Casein kinase 1 delta (CK1δ) | Casein kinase I delta | Casein kinase I isoform alpha/delta | Casein kinase I isoform delta (CK1D) | HCKID | KC1D_HUMAN | casein kinases 1 delta (CK1 delta)
Type:
Enzyme
Mol. Mass.:
47356.76
Organism:
Homo sapiens (Human)
Description:
P48730
Residue:
415
Sequence:
MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNISSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
Inhibitor
Name:
BDBM274891
Synonyms:
N-(6-(7-(Cyclopropanecarbonyl)-2-(4- fluorophenyl)-5,6,7,8-tetrahydroimidazo [1,2- a]pyrazin-3-yl)imidazo[1,2-b]pyridazin-2-yl)-2- fluoroisonicotinamide | US9556179, Compound 469
Type:
Small organic molecule
Emp. Form.:
C28H22F2N8O2
Mol. Mass.:
540.5235
SMILES:
Fc1ccc(cc1)-c1nc2CN(CCn2c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)C(=O)C1CC1