Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM274935
Substrate
n/a
Meas. Tech.
Intracellular Calcium Assay
IC50
44.0±n/a nM
Citation
 Kuduk, SD; Skudlarek, JW Piperidinyloxy lactone orexin receptor antagonists US Patent  US9556190 Publication Date 1/31/2017 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM274935
Synonyms:
1,1-dimethyl-4-(((3R,6R)-6-methyl-1- (2-(pyrimidin-2-yl)thiophene-3- carbonyl)piperidin-3-yl)oxy)furo[3,4- c]pyridin-3(1H)-one | US9556190, Example 25
Type:
Small organic molecule
Emp. Form.:
C24H24N4O4S
Mol. Mass.:
464.537
SMILES:
C[C@@H]1CC[C@H](CN1C(=O)c1ccsc1-c1ncccn1)Oc1nccc2c1C(=O)OC2(C)C |r|
Structure:
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