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Target
Substance-K receptor
Ligand
BDBM50000041
Substrate
n/a
Ki
>10000±n/a nM
Comments
PDSP_574
Citation
 Sarau, HM; Griswold, DE; Potts, W; Foley, JJ; Schmidt, DB; Webb, EF; Martin, LD; Brawner, ME; Elshourbagy, NA; Medhurst, AD; Giardina, GA; Hay, DW Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist. J Pharmacol Exp Ther 281:1303-11 (1997) [PubMed] 
Target
Name:
Substance-K receptor
Synonyms:
NK-2 receptor | NK-2R | NK2R | NK2R_HUMAN | NKNAR | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | Neurokinin-2 (NK-2) | Neuromedin-2 receptor (NK-2R) | SKR | TAC2R | TACR2 | Tachykinin receptor 2 | Tachykinin receptor 2 (NK2) | hnk-3
Type:
Protein
Mol. Mass.:
44455.78
Organism:
Homo sapiens (Human)
Description:
P21452
Residue:
398
Sequence:
MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILAHRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATKCVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLRHLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMAGDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
  
Inhibitor
Name:
BDBM50000041
Synonyms:
(+) (2-Methoxy-benzyl)-(2-phenyl-piperidin-3-yl)-amine | (+)-(2-Methoxy-benzyl)-(2-phenyl-piperidin-3-yl)-amine | (+/-)(2-Methoxy-benzyl)-(2-phenyl-piperidin-3-yl)-amine | (-) (2-Methoxy-benzyl)-(2-phenyl-piperidin-3-yl)-amine | (-)-(2-Methoxy-benzyl)-(2-phenyl-piperidin-3-yl)-amine | (2-Methoxy-benzyl)-((1R,4S)-2-phenyl-piperidin-4-yl)-amine | (2-Methoxy-benzyl)-((2S,3S)-2-phenyl-piperidin-3-yl)-amine | (2-Methoxy-benzyl)-(2-phenyl-piperidin-3-yl)-amine | (2S,3S)-3-(2-Methoxy-benzyloxy)-2-phenyl-piperidine | (2S,3S)-N-(2-methoxybenzyl)-2-phenylpiperidin-3-amine | CHEMBL2114310 | CHEMBL441225 | CP 99994 | CP-99994 | Tritiated-(2-Methoxy-benzyl)-(2-phenyl-piperidin-3-yl)-amine
Type:
Small organic molecule
Emp. Form.:
C19H24N2O
Mol. Mass.:
296.4067
SMILES:
COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1
Structure:
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