Reaction Details Report a problem with these data
Target
Mitogen-activated protein kinase 1
Ligand
BDBM275405
Substrate
n/a
Meas. Tech.
IMAP-FP Assay
IC50
24±n/a nM
Citation
 Siliphaivanh, P; Methot, J; Lipford, KA; Molinari, D; Sloman, DL; Witter, D; Zhou, H; Boyce, C; Huang, X; Lim, J; Guerin, D; Karunakaran, GB; Bakshi, RK; Liu, Z; Fu, J; Wan, Z; Liu, W ERK inhibitors US Patent  US9884048 Publication Date 2/6/2018 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM275405
Synonyms:
1-[(3S,4S)-4-(4- fluorophenoxy)pyrrolidin-3- yl]-3-[1-(2-methylpyridin-4- yl)-1H-pyrazolo[3,4-c]pyridin- 5-yl]urea | US9884048, Example 284
Type:
Small organic molecule
Emp. Form.:
C23H22FN7O2
Mol. Mass.:
447.4649
SMILES:
Cc1cc(ccn1)-n1ncc2cc(NC(=O)N[C@H]3CNC[C@@H]3Oc3ccc(F)cc3)ncc12 |r|
Structure:
Search PDB for entries with ligand similarity: