Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM86290
Substrate
n/a
Ki
91.20±n/a nM
Comments
PDSP_3133
Citation
 De Amici, M; Conti, P; Fasoli, E; Barocelli, E; Ballabeni, V; Bertoni, S; Impicciatore, M; Roth, BL; Ernsberger, P; De Micheli, C Synthesis and in vitro pharmacology of novel heterocyclic muscarinic ligands. Farmaco 58:739-48 (2003) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM86290
Synonyms:
3-[4-(2-Methyl-1H-imidazol-1-yl)-2-butynyl]oxy-delta2-isoxazoline sesquifumarate
Type:
Small organic molecule
Emp. Form.:
C11H13N3O2
Mol. Mass.:
219.2398
SMILES:
Cc1nccn1CC#CCOC1=NOCC1 |t:12|
Structure:
Search PDB for entries with ligand similarity: