Reaction Details Report a problem with these data
Target
P2X purinoceptor 2
Ligand
BDBM18135
Substrate
n/a
Ki
506±n/a nM
Comments
PDSP_4077
Citation
 Jarvis, MF; Bianchi, B; Uchic, JT; Cartmell, J; Lee, CH; Williams, M; Faltynek, C [3H]A-317491, a novel high-affinity non-nucleotide antagonist that specifically labels human P2X2/3 and P2X3 receptors. J Pharmacol Exp Ther 310:407-16 (2004) [PubMed]  Article 
Target
Name:
P2X purinoceptor 2
Synonyms:
ATP receptor | P2RX2 | P2RX2_HUMAN | P2X2 | Purinergic receptor | PurinergicP2X2/3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51765.18
Organism:
Homo sapiens (Human)
Description:
PurinergicP2X2/3 0 HUMAN::Q9UBL9
Residue:
471
Sequence:
MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL
  
Inhibitor
Name:
BDBM18135
Synonyms:
({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}methyl)phosphonic acid | AMPPCP | ATP,Beta Gamma-me | CHEMBL133463 | adenylylmethylenediphosphonate
Type:
Nucleoside or nucleotide
Emp. Form.:
C11H18N5O12P3
Mol. Mass.:
505.2082
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O |r|
Structure:
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