Reaction Details
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Glycerophosphocholine phosphodiesterase GPCPD1
Ligand
BDBM14777
Substrate
n/a
Ki
9.77±n/a nM
Comments
PDSP_6938
Citation
Teixeira, CE; Priviero, FB; Webb, RC Differential effects of the phosphodiesterase type 5 inhibitors sildenafil, vardenafil, and tadalafil in rat aorta. J Pharmacol Exp Ther 316:654-61 (2006) [PubMed] Article More Info.:
Target
Name:
Glycerophosphocholine phosphodiesterase GPCPD1
Synonyms:
GPCP1_RAT | Gde5 | Gpcpd1 | Phosphodiesterase 5 | Putative glycerophosphocholine phosphodiesterase GPCPD1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
76256.67
Organism:
RAT
Description:
Phosphodiesterase 5 0 RAT::Q80VJ4
Residue:
672
Sequence:
MTPSQVTFEIRGTLLPGEVFAMCGNCDALGNWSPQNAVPLTESETGESVWKAVIVLSRGMSVKYRYFRGCFLEPKTIGGPCQVIVHKWETHLQPRSITPLENEIIIDDGQFGIHNGVETLDSGWLTCQTEIRLRLHFSEKPPVSITKKKFKKSRFRVKLTLEGLEEDDDDDDKASPTVLHKMSNSLEISLISDNEFKCRHSQPECGYGLQPDRWTEYSIQTMEPDNLELIFDFFEEDLSEHVVQGDVLPGHVGTACLLSSTIAESERSAGILTLPIMSRSSRKTIGKVRVDFIIIKPLPGYSCSMQSSFSKYWKPRIPLDVGHRGAGNSTTTAKLAKVQENTIASLRNAASHGAAFVEFDVHLSKDLVPVVYHDLTCCLTMKRKYEADPVELFEIPVKELTFDQLQLLKLSHVTALKTKDQKQCMAEEENSFSENQPFPSLKMVLESLPENVGFNIEIKWICQHRDGVWDGNLSTYFDMNAFLDIILKTVLENSGKRRIVFSSFDADICTMVRQKQNKYPILFLTQGKSDIYPELMDLRSRTTPIAMSFAQFENILGINAHTEDLLRNPSYVQEAKDKGLVIFCWGDDTNDPENRRKLKEFGVNGLIYDRIYDWMPEQPNIFQVEQLERLKRELPELKNCLCPTVSHFIPPSFCMESKIHVDANGIDNVENA
Inhibitor
Name:
BDBM14777
Synonyms:
(2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11(16),12,14-tetraene-4,7-dione | (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1,2,1,6]pyrido[3,4-b]indole-1,4-dione | CHEMBL779 | Cialis | GF 196960 | Tadalafil
Type:
Small organic molecule
Emp. Form.:
C22H19N3O4
Mol. Mass.:
389.404
SMILES:
[H][C@]12Cc3c([nH]c4ccccc34)[C@H](N1C(=O)CN(C)C2=O)c1ccc2OCOc2c1 |r|
Structure:
