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Target
26S proteasome non-ATPase regulatory subunit 14
Ligand
BDBM40309
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay
IC50
7280±596 nM
Citation
 PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
26S proteasome non-ATPase regulatory subunit 14
Synonyms:
26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein
Type:
Protein
Mol. Mass.:
34576.68
Organism:
Homo sapiens (Human)
Description:
O00487
Residue:
310
Sequence:
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK
  
Inhibitor
Name:
BDBM40309
Synonyms:
MLS000046765 | N-(3-azepan-1-ylpropyl)-5-{[(2-fluorobenzyl)sulfonyl]methyl}-2-furamide | N-[3-(1-azepanyl)propyl]-5-[(2-fluorophenyl)methylsulfonylmethyl]-2-furancarboxamide | N-[3-(azepan-1-yl)propyl]-5-[(2-fluorobenzyl)sulfonylmethyl]-2-furamide | N-[3-(azepan-1-yl)propyl]-5-[(2-fluorophenyl)methylsulfonylmethyl]furan-2-carboxamide | SMR000032776 | cid_3241115
Type:
Small organic molecule
Emp. Form.:
C22H29FN2O4S
Mol. Mass.:
436.54
SMILES:
Fc1ccccc1CS(=O)(=O)Cc1ccc(o1)C(=O)NCCCN1CCCCCC1
Structure:
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