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Target
26S proteasome non-ATPase regulatory subunit 14
Ligand
BDBM88839
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay
IC50
4180±290 nM
Citation
 PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
26S proteasome non-ATPase regulatory subunit 14
Synonyms:
26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein
Type:
Protein
Mol. Mass.:
34576.68
Organism:
Homo sapiens (Human)
Description:
O00487
Residue:
310
Sequence:
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK
  
Inhibitor
Name:
BDBM88839
Synonyms:
(4Z)-4-[(2-methyl-1H-indol-3-yl)methylene]-2-phenyl-2-oxazolin-5-one | (4Z)-4-[(2-methyl-1H-indol-3-yl)methylidene]-2-phenyl-1,3-oxazol-5-one | (4Z)-4-[(2-methyl-1H-indol-3-yl)methylidene]-2-phenyl-5-oxazolone | MLS000536012 | SMR000155333 | cid_5397501
Type:
Small organic molecule
Emp. Form.:
C19H14N2O2
Mol. Mass.:
302.3267
SMILES:
Cc1[nH]c2ccccc2c1\C=C1/N=C(OC1=O)c1ccccc1 |c:14|
Structure:
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