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Target
26S proteasome non-ATPase regulatory subunit 14
Ligand
BDBM48851
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay
IC50
19500±1150 nM
Citation
 PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
26S proteasome non-ATPase regulatory subunit 14
Synonyms:
26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein
Type:
Protein
Mol. Mass.:
34576.68
Organism:
Homo sapiens (Human)
Description:
O00487
Residue:
310
Sequence:
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK
  
Inhibitor
Name:
BDBM48851
Synonyms:
2-[6-(2-fluorobenzyl)-4-keto-5,7-dimethyl-pyrrolo[3,4-d]pyridazin-3-yl]-N-(2,3,5,6-tetrafluorophenyl)acetamide | 2-[6-(2-fluorobenzyl)-5,7-dimethyl-1-oxo-1,6-dihydro-2H-pyrrolo[3,4-d]pyridazin-2-yl]-N-(2,3,5,6-tetrafluorophenyl)acetamide | 2-[6-[(2-fluorophenyl)methyl]-5,7-dimethyl-4-oxidanylidene-pyrrolo[3,4-d]pyridazin-3-yl]-N-[2,3,5,6-tetrakis(fluoranyl)phenyl]ethanamide | 2-[6-[(2-fluorophenyl)methyl]-5,7-dimethyl-4-oxo-3-pyrrolo[3,4-d]pyridazinyl]-N-(2,3,5,6-tetrafluorophenyl)acetamide | 2-[6-[(2-fluorophenyl)methyl]-5,7-dimethyl-4-oxopyrrolo[3,4-d]pyridazin-3-yl]-N-(2,3,5,6-tetrafluorophenyl)acetamide | MLS000660595 | SMR000310114 | cid_16194171
Type:
Small organic molecule
Emp. Form.:
C23H17F5N4O2
Mol. Mass.:
476.3987
SMILES:
Cc1n(Cc2ccccc2F)c(C)c2c1cnn(CC(=O)Nc1c(F)c(F)cc(F)c1F)c2=O
Structure:
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