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Target
26S proteasome non-ATPase regulatory subunit 14
Ligand
BDBM79278
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay
IC50
3310±254 nM
Citation
 PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
26S proteasome non-ATPase regulatory subunit 14
Synonyms:
26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein
Type:
Protein
Mol. Mass.:
34576.68
Organism:
Homo sapiens (Human)
Description:
O00487
Residue:
310
Sequence:
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK
  
Inhibitor
Name:
BDBM79278
Synonyms:
2-(2,4-diketo-1,3-diazaspiro[4.4]nonan-3-yl)-N-[5-[(4-methoxyphenyl)sulfamoyl]-2-methyl-phenyl]acetamide | 2-(2,4-dioxo-1,3-diazaspiro[4.4]nonan-3-yl)-N-[5-[(4-methoxyphenyl)sulfamoyl]-2-methylphenyl]acetamide | 2-[2,4-bis(oxidanylidene)-1,3-diazaspiro[4.4]nonan-3-yl]-N-[5-[(4-methoxyphenyl)sulfamoyl]-2-methyl-phenyl]ethanamide | MLS002171413 | SMR001251708 | cid_16319329
Type:
Small organic molecule
Emp. Form.:
C23H26N4O6S
Mol. Mass.:
486.541
SMILES:
COc1ccc(NS(=O)(=O)c2ccc(C)c(NC(=O)CN3C(=O)NC4(CCCC4)C3=O)c2)cc1
Structure:
Search PDB for entries with ligand similarity: