Reaction Details Report a problem with these data
Target
26S proteasome non-ATPase regulatory subunit 14
Ligand
BDBM89017
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay
IC50
4690±511 nM
Citation
 PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
26S proteasome non-ATPase regulatory subunit 14
Synonyms:
26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein
Type:
Protein
Mol. Mass.:
34576.68
Organism:
Homo sapiens (Human)
Description:
O00487
Residue:
310
Sequence:
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK
  
Inhibitor
Name:
BDBM89017
Synonyms:
(4-aminophenyl)-diethyl-amine | 4-N,4-N-diethylbenzene-1,4-diamine | MLS002454419 | N,N-Diethyl-p-phenylenediamine | N4,N4-diethylbenzene-1,4-diamine | SMR001372013 | cid_7120
Type:
Small organic molecule
Emp. Form.:
C10H16N2
Mol. Mass.:
164.2474
SMILES:
CCN(CC)c1ccc(N)cc1
Structure:
Search PDB for entries with ligand similarity: