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Target
26S proteasome non-ATPase regulatory subunit 14
Ligand
BDBM89037
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay
IC50
8480±1340 nM
Citation
 PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
26S proteasome non-ATPase regulatory subunit 14
Synonyms:
26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein
Type:
Protein
Mol. Mass.:
34576.68
Organism:
Homo sapiens (Human)
Description:
O00487
Residue:
310
Sequence:
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK
  
Inhibitor
Name:
BDBM89037
Synonyms:
2-(3-bromophenyl)-6-chloranyl-3-[(2-methoxyphenyl)methyl]imidazo[1,2-a]pyridine | 2-(3-bromophenyl)-6-chloro-3-[(2-methoxyphenyl)methyl]imidazo[1,2-a]pyridine | 2-(3-bromophenyl)-6-chloro-3-o-anisyl-imidazo[1,2-a]pyridine | MLS003322128 | SMR002002143 | cid_51360607
Type:
Small organic molecule
Emp. Form.:
C21H16BrClN2O
Mol. Mass.:
427.722
SMILES:
COc1ccccc1Cc1c(nc2ccc(Cl)cn12)-c1cccc(Br)c1
Structure:
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