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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM77413
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM77413
Synonyms:
4-(benzenesulfonyl)-5-(4-fluorophenyl)-1-phenylpyrazole | 4-besyl-5-(4-fluorophenyl)-1-phenyl-pyrazole | 5-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl phenyl sulfone | 5-(4-fluorophenyl)-1-phenyl-4-(phenylsulfonyl)pyrazole | MLS000546418 | SMR000169588 | cid_1483453
Type:
Small organic molecule
Emp. Form.:
C21H15FN2O2S
Mol. Mass.:
378.419
SMILES:
Fc1ccc(cc1)-c1c(cnn1-c1ccccc1)S(=O)(=O)c1ccccc1
Structure:
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