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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM74882
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
18300±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM74882
Synonyms:
(2Z)-2-[(4-acetylphenyl)hydrazono]-2-(2-anilinothiazol-4-yl)acetic acid ethyl ester | 2-[(4-acetylphenyl)hydrazinylidene]-2-(2-anilino-4-thiazolyl)acetic acid ethyl ester | 2-[(4-acetylphenyl)hydrazono]-2-(2-anilinothiazol-4-yl)acetic acid ethyl ester | MLS000699913 | SMR000225145 | cid_15945033 | ethyl 2-[(4-acetylphenyl)hydrazinylidene]-2-(2-anilino-1,3-thiazol-4-yl)acetate | ethyl 2-[(4-ethanoylphenyl)hydrazinylidene]-2-(2-phenylazanyl-1,3-thiazol-4-yl)ethanoate | ethyl [(4-acetylphenyl)hydrazono](2-anilino-1,3-thiazol-4-yl)acetate
Type:
Small organic molecule
Emp. Form.:
C21H20N4O3S
Mol. Mass.:
408.473
SMILES:
CCOC(=O)C(=NNc1ccc(cc1)C(C)=O)c1csc(Nc2ccccc2)n1 |w:6.6|
Structure:
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