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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM53096
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
7640±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM53096
Synonyms:
2-[3-[(E)-(2,4,6-triketo-1-phenyl-hexahydropyrimidin-5-ylidene)methyl]indol-1-yl]acetic acid methyl ester | 2-[3-[(E)-(2,4,6-trioxo-1-phenyl-1,3-diazinan-5-ylidene)methyl]-1-indolyl]acetic acid methyl ester | MLS001211824 | SMR000517477 | [3-(2,4,6-Trioxo-1-phenyl-tetrahydro-pyrimidin-5-ylidenemethyl)-indol-1-yl]-acetic acid methyl ester | cid_1921295 | methyl 2-[3-[(E)-(2,4,6-trioxo-1-phenyl-1,3-diazinan-5-ylidene)methyl]indol-1-yl]acetate | methyl 2-[3-[(E)-[2,4,6-tris(oxidanylidene)-1-phenyl-1,3-diazinan-5-ylidene]methyl]indol-1-yl]ethanoate
Type:
Small organic molecule
Emp. Form.:
C22H17N3O5
Mol. Mass.:
403.3875
SMILES:
COC(=O)Cn1cc(C=C2C(=O)NC(=O)N(C2=O)c2ccccc2)c2ccccc12 |w:8.7|
Structure:
Search PDB for entries with ligand similarity: