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Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM14605
Substrate
n/a
Meas. Tech.
Abbott Kinase Enzymatics_CHK1/289 CDC25c
IC50
4±n/a nM
Citation
 CSARdock, CD CHK1 in CSAR_FULL_RELEASE_3JULY2012 CSAR 1:0 (2012)  
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM14605
Synonyms:
1-(4-amino-5-chloro-2-methoxyphenyl)-3-(5-cyanopyrazin-2-yl)urea | Chk1_76 | N-pyrazinylurea Analog 7
Type:
Small organic molecule
Emp. Form.:
C13H11ClN6O2
Mol. Mass.:
318.718
SMILES:
COc1cc(N)c(Cl)cc1NC(=O)Nc1cnc(cn1)C#N
Structure:
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