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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM279195
Substrate
n/a
Meas. Tech.
Human indoleamine 2,3-dioxygenasae (IDO) enzyme assay
pH
6.5±n/a
Temperature
298.15±n/a K
IC50
<200±n/a nM
Comments
extracted
Citation
 Gajewski, TF; Spranger, S; Leung, M Synergistic combination of immunologic inhibitors for the treatment of cancer US Patent  US10034939 Publication Date 7/31/2018 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM279195
Synonyms:
4-(2-[(Aminosulfonyl)(methyl)amino]ethylamino)-N-(3-chloro-4-fluorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide | US10034939, Example 24 | US10967060, Example 24
Type:
Small organic molecule
Emp. Form.:
C12H15ClFN7O4S
Mol. Mass.:
407.808
SMILES:
CN(CCNc1nonc1\C(Nc1ccc(F)c(Cl)c1)=N\O)S(N)(=O)=O
Structure:
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