Reaction Details Report a problem with these data
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM92602
Substrate
n/a
Meas. Tech.
Continuous Assay
IC50
5.6e+3± 4e+2 nM
Citation
Patel, V; Booker, M; Kramer, M; Ross, L; Celatka, CA; Kennedy, LM; Dvorin, JD; Duraisingh, MT; Sliz, P; Wirth, DF; Clardy, J Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem 283:35078-85 (2008) [PubMed] Article
More Info.:
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial, putative
Type:
PROTEIN
Mol. Mass.:
62972.27
Organism:
Plasmodium vivax
Description:
A5K1N1
Residue:
572
Sequence:
MLRHSCLREKGNLIGGSLLRGISAQLRAAGGGTFRSFHSYRSFCSFCIFRRANKADANWYGCFPGHVAGGATCGPLRGDCAERHKLMAHVRRFSGESTRAKGGDKREGDIEGNRTNGSDKTKQLEEEMKKLNEQIAREKGNHKKALLFIFTCVVALYMYFESYDPEFFLYDVFLKMLLKYVDGETCHELFLLMGKYKLLPYDTGKDNIYSCSEIKGLNFINPFGVAAGFDKNGVCIDGILKLGFSFIEIGTITPKAQKGNERPRIFRDLETRSIINSCGFNNMGCDEVCKNLKRFRERQKTDKLLQRHLVGVSLGKNKDSPDILQDLSYCIGKIGRYADYIAINVSSPNTPGLRDHQKGERLHGIIQRVKEEVAKLDGGGAPLGGATTGGAAMGGATTGEAVVGKAPPDEAATGGEPWANTTKRRPLIFVKLAPDLEEGERKSIANVLLNAEVDGMIICNTTTQKFNIKSFEDKKGGVSGEKLKGVSTHMISQMYNYTNGKIPIIASGGIFTGEDALEKIEAGASVCQLYSCLVFNGMKAAVRIKRELDHLLYQRGYYKLGDAVGRAHRRAA