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Target
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Ligand
BDBM92938
Substrate
n/a
Meas. Tech.
LpxC Assay
IC50
>5.00e+5±n/a nM
Citation
 Barb, AW; Leavy, TM; Robins, LI; Guan, Z; Six, DA; Zhou, P; Hangauer, MJ; Bertozzi, CR; Raetz, CR Uridine-based inhibitors as new leads for antibiotics targeting Escherichia coli LpxC. Biochemistry 48:3068-77 (2009) [PubMed]  Article 
Target
Name:
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Synonyms:
LPXC_ECOLI | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC) | UDP-3-O-acyl-GlcNAc deacetylase | asmB | envA | lpxC
Type:
Enzyme
Mol. Mass.:
33952.00
Organism:
Escherichia coli
Description:
P0A725
Residue:
305
Sequence:
MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAPSAVLA
  
Inhibitor
Name:
BDBM92938
Synonyms:
1-68Ad analogue
Type:
Small molecule
Emp. Form.:
C16H17N3O9
Mol. Mass.:
395.3209
SMILES:
OC1C(CO\N=C\c2cc(O)c(O)c(O)c2)OC(C1O)n1ccc(=O)[nH]c1=O
Structure:
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