Reaction Details Report a problem with these data
Target
NADH-ubiquinone oxidoreductase chain 1
Ligand
BDBM92955
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
2.2±0.20 nM
Citation
 Ichimaru, N; Murai, M; Kakutani, N; Kako, J; Ishihara, A; Nakagawa, Y; Nishioka, T; Yagi, T; Miyoshi, H Synthesis and characterization of new piperazine-type inhibitors for mitochondrial NADH-ubiquinone oxidoreductase (complex I). Biochemistry 47:10816-26 (2008) [PubMed]  Article 
Target
Name:
NADH-ubiquinone oxidoreductase chain 1
Synonyms:
MT-ND1 | MTND1 | NADH Oxidase | NADH-ubiquinone oxidoreductase | NADH-ubiquinone oxidoreductase chain 1 | NADH1 | ND1 | NU1M_BOVIN
Type:
Protein
Mol. Mass.:
35672.63
Organism:
Bos taurus (Bovine)
Description:
P03887
Residue:
318
Sequence:
MFMINILMLIIPILLAVAFLTLVERKVLGYMQLRKGPNVVGPYGLLQPIADAIKLFIKEPLRPATSSASMFILAPIMALGLALTMWIPLPMPYPLINMNLGVLFMLAMSSLAVYSILWSGWASNSKYALIGALRAVAQTISYEVTLAIILLSVLLMSGSFTLSTLITTQEQMWLILPAWPLAMMWFISTLAETNRAPFDLTEGESELVSGFNVEYAAGPFALFFMAEYANIIMMNIFTAILFLGTSHNPHMPELYTINFTIKSLLLTMSFLWIRASYPRFRYDQLMHLLWKNFLPLTLALCMWHVSLPILTSGIPPQT
  
Inhibitor
Name:
BDBM92955
Synonyms:
Piperazine derivative, 19
Type:
Small molecule
Emp. Form.:
C32H50N2
Mol. Mass.:
462.7528
SMILES:
C(CCCCc1ccccc1)CCCN1CCN(CCCCCCCCc2ccccc2)CC1
Structure:
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