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Target
Receptor-interacting serine/threonine-protein kinase 2
Ligand
BDBM63629
Substrate
n/a
IC50
3251±n/a nM
Citation
 PubChem, PC Fluorescence-based cell-based high throughput dose response assay for inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and the receptor-interacting serine-threonine kinase 2 (RIPK2) PubChem Bioassay (2012)[AID] 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 2
Synonyms:
CARDIAK | RICK | RIP2 | RIPK2 | RIPK2_HUMAN | Serine/threonine-protein kinase RIPK2 | Tyrosine-protein kinase RIPK2 | receptor-interacting serine/threonine-protein kinase 2
Type:
Protein
Mol. Mass.:
61201.30
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
540
Sequence:
MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
  
Inhibitor
Name:
BDBM63629
Synonyms:
4,5-bis(bromanyl)-2-(4-methylphenyl)pyridazin-3-one | 4,5-dibromo-2-(4-methylphenyl)-3(2H)-pyridazinone | 4,5-dibromo-2-(4-methylphenyl)-3-pyridazinone | 4,5-dibromo-2-(4-methylphenyl)pyridazin-3-one | 4,5-dibromo-2-(p-tolyl)pyridazin-3-one | MLS000720992 | SMR000335544 | cid_1487485
Type:
Small organic molecule
Emp. Form.:
C11H8Br2N2O
Mol. Mass.:
344.002
SMILES:
Cc1ccc(cc1)-n1ncc(Br)c(Br)c1=O
Structure:
Search PDB for entries with ligand similarity: