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Target
Sentrin-specific protease 8
Ligand
BDBM81247
Substrate
n/a
IC50
2830±216 nM
Citation
 PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using a kinetic assay with Nedd8 Protein Substrate PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 8
Synonyms:
DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24104.52
Organism:
Homo sapiens (Human)
Description:
gi_262118306
Residue:
212
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLITTLAKK
  
Inhibitor
Name:
BDBM81247
Synonyms:
1-[(5-azanyl-4-methyl-isoquinolin-1-yl)methylideneamino]thiourea | MLS002702098 | SMR001565666 | [(5-amino-4-methyl-1-isoquinolinyl)methylideneamino]thiourea | [(5-amino-4-methyl-1-isoquinolyl)methyleneamino]thiourea | [(5-amino-4-methylisoquinolin-1-yl)methylideneamino]thiourea | cid_3035508
Type:
Small organic molecule
Emp. Form.:
C12H13N5S
Mol. Mass.:
259.33
SMILES:
Cc1cnc(C=NNC(N)=S)c2cccc(N)c12 |w:6.6|
Structure:
Search PDB for entries with ligand similarity: