Reaction Details Report a problem with these data
Target
Sentrin-specific protease 8
Ligand
BDBM64786
Substrate
n/a
IC50
2300±162 nM
Citation
 PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using a kinetic assay with Nedd8 Protein Substrate PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 8
Synonyms:
DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24104.52
Organism:
Homo sapiens (Human)
Description:
gi_262118306
Residue:
212
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLITTLAKK
  
Inhibitor
Name:
BDBM64786
Synonyms:
1-(2,1,3-benzothiadiazol-5-yl)-3-(4-methoxyphenyl)thiourea | 1-(4-methoxyphenyl)-3-piazthiol-5-yl-thiourea | MLS000585342 | N-2,1,3-benzothiadiazol-5-yl-N'-(4-methoxyphenyl)thiourea | SMR000204105 | cid_753169
Type:
Small organic molecule
Emp. Form.:
C14H12N4OS2
Mol. Mass.:
316.401
SMILES:
COc1ccc(NC(=S)Nc2ccc3nsnc3c2)cc1
Structure:
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