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Target
Sentrin-specific protease 8
Ligand
BDBM93675
Substrate
n/a
IC50
1090±83 nM
Citation
 PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using a kinetic assay with Nedd8 Protein Substrate PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 8
Synonyms:
DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24104.52
Organism:
Homo sapiens (Human)
Description:
gi_262118306
Residue:
212
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLITTLAKK
  
Inhibitor
Name:
BDBM93675
Synonyms:
MLS002608730 | N-(6-methoxy-4-methyl-8-quinolinyl)-N'-propan-2-ylpropane-1,3-diamine | N-(6-methoxy-4-methyl-quinolin-8-yl)-N'-propan-2-yl-propane-1,3-diamine | N-(6-methoxy-4-methylquinolin-8-yl)-N'-propan-2-ylpropane-1,3-diamine | SMR001527474 | cid_239930 | isopropyl-[3-[(6-methoxy-4-methyl-8-quinolyl)amino]propyl]amine
Type:
Small organic molecule
Emp. Form.:
C17H25N3O
Mol. Mass.:
287.3999
SMILES:
COc1cc(NCCCNC(C)C)c2nccc(C)c2c1
Structure:
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