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Target
Sentrin-specific protease 8
Ligand
BDBM61210
Substrate
n/a
IC50
754±67 nM
Citation
 PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using a kinetic assay with Nedd8 Protein Substrate PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 8
Synonyms:
DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24104.52
Organism:
Homo sapiens (Human)
Description:
gi_262118306
Residue:
212
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLITTLAKK
  
Inhibitor
Name:
BDBM61210
Synonyms:
3-Acetyl-3a,8b-dihydroxy-2-methyl-3a,8b-dihydro-indeno[1,2-b]furan-4-one | 3-acetyl-3a,8b-dihydroxy-2-methyl-4-indeno[1,2-b]furanone | 3-acetyl-3a,8b-dihydroxy-2-methyl-indeno[1,2-b]furan-4-one | 3-acetyl-3a,8b-dihydroxy-2-methylindeno[1,2-b]furan-4-one | 3-ethanoyl-2-methyl-3a,8b-bis(oxidanyl)indeno[1,2-b]furan-4-one | MLS000768249 | SMR000431570 | cid_2828331
Type:
Small organic molecule
Emp. Form.:
C14H12O5
Mol. Mass.:
260.2421
SMILES:
CC(=O)C1=C(C)OC2(O)c3ccccc3C(=O)C12O |c:3|
Structure:
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