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Target
Sentrin-specific protease 1
Ligand
BDBM60553
Substrate
n/a
IC50
8280±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a kinetic FRET assay PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 1
Synonyms:
SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1)
Type:
Protein
Mol. Mass.:
73500.42
Organism:
Homo sapiens (Human)
Description:
Q9P0U3
Residue:
644
Sequence:
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
  
Inhibitor
Name:
BDBM60553
Synonyms:
MLS000390001 | N-[(5-morpholino-2-thienyl)methyleneamino]carbamic acid tert-butyl ester | N-[(E)-(5-morpholino-2-thienyl)methyleneamino]carbamic acid tert-butyl ester | N-[[5-(4-morpholinyl)-2-thiophenyl]methylideneamino]carbamic acid tert-butyl ester | SMR000259265 | cid_2391626 | tert-butyl N-[(5-morpholin-4-ylthiophen-2-yl)methylideneamino]carbamate
Type:
Small organic molecule
Emp. Form.:
C14H21N3O3S
Mol. Mass.:
311.4
SMILES:
CC(C)(C)OC(=O)NN=Cc1ccc(s1)N1CCOCC1 |w:8.7|
Structure:
Search PDB for entries with ligand similarity: