Reaction Details Report a problem with these data
Target
Hepatocyte nuclear factor 4-alpha
Ligand
BDBM94500
Substrate
n/a
IC50
36128±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization PubChem Bioassay (2012)[AID] 
Target
Name:
Hepatocyte nuclear factor 4-alpha
Synonyms:
HNF4 | HNF4A | HNF4A_HUMAN | NR2A1 | TCF14 | hepatocyte nuclear factor 4-alpha isoform b
Type:
PROTEIN
Mol. Mass.:
52790.24
Organism:
Homo sapiens (Human)
Description:
ChEMBL_606516
Residue:
474
Sequence:
MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI
  
Inhibitor
Name:
BDBM94500
Synonyms:
(E)-2-butenedioic acid;1-[2-(dimethylamino)ethylamino]-2-methoxy-4-methyl-9-thioxanthenone | (E)-but-2-enedioic acid;1-[2-(dimethylamino)ethylamino]-2-methoxy-4-methyl-thioxanthen-9-one | (E)-but-2-enedioic acid;1-[2-(dimethylamino)ethylamino]-2-methoxy-4-methylthioxanthen-9-one | 1-[2-(dimethylamino)ethylamino]-2-methoxy-4-methyl-thioxanthen-9-one;fumaric acid | MLS003116011 | SMR001831569 | cid_5384288
Type:
Small organic molecule
Emp. Form.:
C19H22N2O2S
Mol. Mass.:
342.455
SMILES:
COc1cc(C)c2sc3ccccc3c(=O)c2c1NCCN(C)C
Structure:
Search PDB for entries with ligand similarity: