Reaction Details Report a problem with these data
Target
ADP-ribosylation factor GTPase-activating protein 1
Ligand
BDBM95197
Substrate
n/a
IC50
49017±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) PubChem Bioassay (2012)[AID] 
Target
Name:
ADP-ribosylation factor GTPase-activating protein 1
Synonyms:
ARFG1_RAT | Arf1gap | Arfgap1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45436.38
Organism:
Rattus norvegicus
Description:
gi_21489979
Residue:
415
Sequence:
MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQDDYEPSWSLQDKYSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRPAGQPQNVTTSGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNSAMSSLYSGWSSFTTGASKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEDTSDRPLEGHSYQNSSGDNSQNSTIDQSFWETFGSAEPPKAKSPSSDSWTCADASTGRRSSDSWDIWGSGSASNNKNSNSDGWESWEGASGEGRAKATKKAAPSTAADEGWDNQNW
  
Inhibitor
Name:
BDBM95197
Synonyms:
5-({4-nitro-1H-pyrazol-1-yl}methyl)-N'-(4-propoxybenzylidene)-2-furohydrazide | 5-[(4-nitro-1-pyrazolyl)methyl]-N-[(E)-(4-propoxyphenyl)methylideneamino]-2-furancarboxamide | 5-[(4-nitropyrazol-1-yl)methyl]-N-[(E)-(4-propoxybenzylidene)amino]-2-furamide | 5-[(4-nitropyrazol-1-yl)methyl]-N-[(E)-(4-propoxyphenyl)methylideneamino]furan-2-carboxamide | MLS000325124 | SMR000159503 | cid_6873375
Type:
Small organic molecule
Emp. Form.:
C19H19N5O5
Mol. Mass.:
397.3847
SMILES:
CCCOc1ccc(\C=N\NC(=O)c2ccc(Cn3cc(cn3)[N+]([O-])=O)o2)cc1
Structure:
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