Reaction Details Report a problem with these data
Target
Tumor necrosis factor receptor superfamily member 10B
Ligand
BDBM95885
Substrate
n/a
EC50
4840±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for a small molecule Caspase-8 TRAIL sensitizers in a luminescence panel assay PubChem Bioassay (2013)[AID] 
Target
Name:
Tumor necrosis factor receptor superfamily member 10B
Synonyms:
DR5 | KILLER | TNFRSF10B | TR10B_HUMAN | TRAILR2 | TRICK2 | ZTNFR9 | tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens]
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47869.76
Organism:
Homo sapiens (Human)
Description:
gi_224494019
Residue:
440
Sequence:
MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAAVLLLVSAESALITQQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCKSLLWKKVLPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIVSILQPTQVPEQEMEVQEPAEPTGVNMLSPGESEHLLEPAEAERSQRRRLLVPANEGDPTETLRQCFDDFADLVPFDSWEPLMRKLGLMDNEIKVAKAEAAGHRDTLYTMLIKWVNKTGRDASVHTLLDALETLGERLAKQKIEDHLLSSGKFMYLEGNADSAMS
  
Inhibitor
Name:
BDBM95885
Synonyms:
4-methyl-6-phenyl-N-[(E)-(phenylmethylene)amino]-2-pyrimidinamine | 4-methyl-6-phenyl-N-[(E)-(phenylmethylidene)amino]pyrimidin-2-amine | MLS001174417 | N-[(E)-benzylideneamino]-4-methyl-6-phenylpyrimidin-2-amine | SMR000595150 | [(E)-benzalamino]-(4-methyl-6-phenyl-pyrimidin-2-yl)amine | cid_9609324
Type:
Small organic molecule
Emp. Form.:
C18H16N4
Mol. Mass.:
288.3464
SMILES:
Cc1cc(nc(N=NCc2ccccc2)n1)-c1ccccc1 |w:6.5|
Structure:
Search PDB for entries with ligand similarity: