Reaction Details Report a problem with these data
Target
Tumor necrosis factor receptor superfamily member 10B
Ligand
BDBM95991
Substrate
n/a
EC50
7000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for a small molecule Caspase-8 TRAIL sensitizers in a luminescence panel assay PubChem Bioassay (2013)[AID] 
Target
Name:
Tumor necrosis factor receptor superfamily member 10B
Synonyms:
DR5 | KILLER | TNFRSF10B | TR10B_HUMAN | TRAILR2 | TRICK2 | ZTNFR9 | tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens]
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47869.76
Organism:
Homo sapiens (Human)
Description:
gi_224494019
Residue:
440
Sequence:
MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAAVLLLVSAESALITQQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCKSLLWKKVLPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIVSILQPTQVPEQEMEVQEPAEPTGVNMLSPGESEHLLEPAEAERSQRRRLLVPANEGDPTETLRQCFDDFADLVPFDSWEPLMRKLGLMDNEIKVAKAEAAGHRDTLYTMLIKWVNKTGRDASVHTLLDALETLGERLAKQKIEDHLLSSGKFMYLEGNADSAMS
  
Inhibitor
Name:
BDBM95991
Synonyms:
2-(2,4-Dimethyl-benzylsulfanyl)-3-methoxy-3H-quinazolin-4-one | 2-[(2,4-dimethylbenzyl)thio]-3-methoxy-quinazolin-4-one | 2-[(2,4-dimethylphenyl)methylsulfanyl]-3-methoxy-quinazolin-4-one | 2-[(2,4-dimethylphenyl)methylsulfanyl]-3-methoxyquinazolin-4-one | 2-[(2,4-dimethylphenyl)methylthio]-3-methoxy-4-quinazolinone | MLS000557273 | SMR000148190 | cid_932902
Type:
Small organic molecule
Emp. Form.:
C18H18N2O2S
Mol. Mass.:
326.413
SMILES:
COn1c(SCc2ccc(C)cc2C)nc2ccccc2c1=O
Structure:
Search PDB for entries with ligand similarity: