Reaction Details Report a problem with these data
Target
Tumor necrosis factor receptor superfamily member 10B
Ligand
BDBM96049
Substrate
n/a
EC50
4390±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for a small molecule Caspase-8 TRAIL sensitizers in a luminescence panel assay PubChem Bioassay (2013)[AID] 
Target
Name:
Tumor necrosis factor receptor superfamily member 10B
Synonyms:
DR5 | KILLER | TNFRSF10B | TR10B_HUMAN | TRAILR2 | TRICK2 | ZTNFR9 | tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens]
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47869.76
Organism:
Homo sapiens (Human)
Description:
gi_224494019
Residue:
440
Sequence:
MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAAVLLLVSAESALITQQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCKSLLWKKVLPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIVSILQPTQVPEQEMEVQEPAEPTGVNMLSPGESEHLLEPAEAERSQRRRLLVPANEGDPTETLRQCFDDFADLVPFDSWEPLMRKLGLMDNEIKVAKAEAAGHRDTLYTMLIKWVNKTGRDASVHTLLDALETLGERLAKQKIEDHLLSSGKFMYLEGNADSAMS
  
Inhibitor
Name:
BDBM96049
Synonyms:
MLS002473384 | N-[[1-(2-oxobut-3-ynyl)cyclohexyl]methyl]-N-(phenylmethyl)carbamic acid tert-butyl ester | N-benzyl-N-[[1-(2-ketobut-3-ynyl)cyclohexyl]methyl]carbamic acid tert-butyl ester | SMR001397476 | cid_44202097 | tert-butyl N-[[1-(2-oxidanylidenebut-3-ynyl)cyclohexyl]methyl]-N-(phenylmethyl)carbamate | tert-butyl N-benzyl-N-[[1-(2-oxobut-3-ynyl)cyclohexyl]methyl]carbamate
Type:
Small organic molecule
Emp. Form.:
C23H31NO3
Mol. Mass.:
369.4971
SMILES:
CC(C)(C)OC(=O)N(Cc1ccccc1)CC1(CC(=O)C#C)CCCCC1
Structure:
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