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Target
Tumor necrosis factor receptor superfamily member 10B
Ligand
BDBM96085
Substrate
n/a
EC50
5830±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for a small molecule Caspase-8 TRAIL sensitizers in a luminescence panel assay PubChem Bioassay (2013)[AID] 
Target
Name:
Tumor necrosis factor receptor superfamily member 10B
Synonyms:
DR5 | KILLER | TNFRSF10B | TR10B_HUMAN | TRAILR2 | TRICK2 | ZTNFR9 | tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens]
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47869.76
Organism:
Homo sapiens (Human)
Description:
gi_224494019
Residue:
440
Sequence:
MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAAVLLLVSAESALITQQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCKSLLWKKVLPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIVSILQPTQVPEQEMEVQEPAEPTGVNMLSPGESEHLLEPAEAERSQRRRLLVPANEGDPTETLRQCFDDFADLVPFDSWEPLMRKLGLMDNEIKVAKAEAAGHRDTLYTMLIKWVNKTGRDASVHTLLDALETLGERLAKQKIEDHLLSSGKFMYLEGNADSAMS
  
Inhibitor
Name:
BDBM96085
Synonyms:
4-tert-Butyl-N-(2-methyl-2H-tetrazol-5-yl)-benzamide | 4-tert-butyl-N-(2-methyl-1,2,3,4-tetrazol-5-yl)benzamide | 4-tert-butyl-N-(2-methyl-5-tetrazolyl)benzamide | 4-tert-butyl-N-(2-methyltetrazol-5-yl)benzamide | MLS000034411 | SMR000014654 | cid_645076
Type:
Small organic molecule
Emp. Form.:
C13H17N5O
Mol. Mass.:
259.307
SMILES:
Cn1nnc(NC(=O)c2ccc(cc2)C(C)(C)C)n1
Structure:
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