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Target
Genome polyprotein [1027-1657]
Ligand
BDBM97753
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.5±n/a
Temperature
310.15±n/a K
IC50
2±n/a nM
Comments
extracted
Citation
 Casarez, A; Ji, M; Kim, CU; Sheng, XC; Wu, Q Antiviral compounds US Patent  US8476225 Publication Date 7/2/2013 
Target
Name:
Genome polyprotein [1027-1657]
Synonyms:
POLG_HCV1 | Serine protease NS3
Type:
n/a
Mol. Mass.:
67260.74
Organism:
Hepatitis C virus genotype 1a (isolate 1) (HCV)
Description:
1027-1657 aa of P26664
Residue:
631
Sequence:
APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTAAQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHAVGIFRAAVCTRGVAKAVDFIPVENLETTMRSPVFTDNSSPPVVPQSFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGIDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGAYDIIICDECHSTDATSILGIGTVLDQAETAGARLVVLATATPPGSVTVPHPNIEEVALSTTGEIPFYGKAIPLEVIKGGRHLIFCHSKKKCDELAAKLVALGINAVAYYRGLDVSVIPTSGDVVVVATDALMTGYTGDFDSVIDCNTCVTQTVDFSLDPTFTIETITLPQDAVSRTQRRGRTGRGKPGIYRFVAPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENLPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEITLTHPVTKYIMTCMSADLEVVT
  
Inhibitor
Name:
BDBM97753
Synonyms:
US8476225, 14
Type:
Small organic molecule
Emp. Form.:
C31H42BrN5O9S2
Mol. Mass.:
772.727
SMILES:
CC(C)(C)[C@H](NC(=O)OC1CCCC1)C(=O)N1CN(C[C@H]1C(=O)N[C@@]1(C[C@H]1C=C)C(=O)NS(=O)(=O)C1CC1)S(=O)(=O)c1ccc(Br)cc1 |r|
Structure:
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