Reaction Details Report a problem with these data
Target
COUP transcription factor 2
Ligand
BDBM70705
Substrate
n/a
IC50
11294±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay to identify inhibitors of COUP-TFII (NR2F2) PubChem Bioassay (2013)[AID] 
Target
Name:
COUP transcription factor 2
Synonyms:
ARP1 | COT2_HUMAN | COUP transcription factor 2 isoform a | NR2F2 | TFCOUP2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45583.83
Organism:
Homo sapiens (Human)
Description:
gi_14149746
Residue:
414
Sequence:
MAMVVSTWRDPQDEVPGSQGSQASQAPPVPGPPPGAPHTPQTPGQGGPASTPAQTAAGGQGGPGGPGSDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMAIQ
  
Inhibitor
Name:
BDBM70705
Synonyms:
2-[(3-Bromo-benzylsulfanyl)-(4-fluoro-phenylamino)-methylene]-malononitrile | 2-[(3-bromophenyl)methylsulfanyl-(4-fluoroanilino)methylidene]propanedinitrile | 2-[(3-bromophenyl)methylsulfanyl-[(4-fluorophenyl)amino]methylidene]propanedinitrile | 2-[[(3-bromobenzyl)thio]-(4-fluoroanilino)methylene]malononitrile | 2-[[(3-bromophenyl)methylthio]-(4-fluoroanilino)methylidene]propanedinitrile | MLS000590962 | SMR000217798 | cid_3741479
Type:
Small organic molecule
Emp. Form.:
C17H11BrFN3S
Mol. Mass.:
388.257
SMILES:
Fc1ccc(cc1)N=C(SCc1cccc(Br)c1)C(C#N)C#N |w:7.7|
Structure:
Search PDB for entries with ligand similarity: