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Target
Mu-type opioid receptor
Ligand
BDBM102409
Substrate
n/a
Meas. Tech.
Binding Assay
Temperature
298.15±0 K
Ki
17.27±0.0 nM
Citation
 Inagaki, M; Hara, S; Haga, N; Tamura, Y; Goto, Y; Hasegawa, T 6,7-unsaturated-7-carbamoyl substituted morphinan derivative US Patent  US8536192 Publication Date 9/17/2013 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM102409
Synonyms:
US8536192, I-188
Type:
Small organic molecule
Emp. Form.:
C28H28N2O7
Mol. Mass.:
504.5311
SMILES:
OC(=O)c1cccc(NC(=O)C2C[C@@]3(O)[C@H]4Cc5ccc(O)c6O[C@@H](C2=O)[C@]3(CCN4CC2CC2)c56)c1 |r,TLB:12:13:35.17.16:28.30.29,THB:14:13:35.17.16:28.30.29|
Structure:
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